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Analytical science and quality writing from the laboratory — what each measurement can and cannot tell you, how to read a certificate, and how to investigate a result that does not agree with another one.

Peptide analysis

20 October 2026 · Peptide Analysis & Quality Control · 12 min

How to read a peptide certificate of analysis (COA): a complete guide

What each field on a certificate establishes and what it does not — batch traceability, identity, HPLC purity, net peptide content, how to read a chromatogram, what an unknown UV-active peak means, and the seven warning signs worth a second look.

Peptide COA COA verification Chromatograms Batch traceability

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20 October 2026 · Peptide Analysis · 9 min

HPLC purity vs. net peptide content: what’s the difference?

A vial can test at 99% chromatographic purity and still hold less peptide than its label claims — the two numbers answer different questions. Where water, counterions, residual solvents and excipients go, and why area normalization is not a mass balance.

HPLC testing Net peptide content Quantitative analysis COA interpretation

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Analytical science & quality insights

19 October 2026 · Analytical Science & Quality Insights · 8 min

Beyond 99% purity: what recent peptide manufacturing investigations reveal about analytical quality

FDA inspectors documented contamination and documentation failures at two overseas facilities making GLP-1 ingredients, and a peer-reviewed study found that products advertised at 99% purity contained 7.7% to 14.4% peptide by mass. Both point at the same question: what does a purity percentage actually establish?

Peptide purity HPLC analysis COA verification GLP-1 analysis

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Writing here is for scientific and educational purposes. It does not constitute certification of any product, manufacturer or laboratory, and references to regulatory guidance do not imply approval, accreditation or endorsement of Sycamore Analytical. Confirm analytical capabilities and service availability with the laboratory directly.